Ending an epidemic is a marathon undertaking, and in the case of malaria, we are nearing the finish line. But we will need to keep up the momentum. Still, mounting challenges such as drug and insecticide resistance threaten to reverse the progress we have made. For two consecutive years now, malaria deaths have risen, while funding has flatlined. This year’s World Malaria Day (April 25) should thus spur a redoubling of our efforts. Eradicating malaria will require new medical and health-policy solutions as well as stronger political will.